Genie in Bottle: Cellular Bioengineering, Inc.

As published in 2008 Fall, Upload - The Quarterly Journal for Science & Technology in Hawaii.

The wellspring of innovation can be a strange and quirky place. Moili'ili-based Cellular Bioengineering is a master at mining the well, finding "Aha!" moments even in an "Oops!" The company got off the ground in 2003 with its bioengineered corneal tissue. That project is well on its way to helping the world's 10 million people with corneal blindness.

In the meantime, the folks at CBI noticed certain properties in the corneal hydrogel - they transmogrified it and created a new material that cleans radioactive uranium in wounds. Then they created another version that sops up radioactive and nuclear contamination at nuclear power plants and research labs. Existing standard procedure for spills is often soap and water, Windex or duct tape - so folks at CBI think they're onto a good thing. This gel contains and cleans up toxic contaminants, while sterilizing down to the microscopic level.

Then, one morning, researchers came into the lab to find a bottle of the gel had tipped over (Oops!) spilling its contents on the floor. Cleaning up, the noticed the floor was super clean (Aha!). So, they worked some more and created yet more versions.

As it turns out, the nonsmelly, user-friendly, wipe-on, peel-off hydrogel can deal with the leavings of everyone from terrorists to toddlers. It has been shown to be effective against the drug-resistant "superbug" MRSA, which can be a life-threatening problem in hospitals, as well as against chemical and biological agents that could be used in a terrorist attack.

The commercial version of the gel, which has the internal code name of GenieGel, works on stained boat hulls, algae red dirt, mold; it even cleaned a bathroom at McKinley High School that had be trammeled by decades of dirt.

Division general manager Roberto Mandanas sees a market for the hydrogel family in homes, hospitals, industries - and a bottle of it next to every fire extinguisher in every public building across the country.

The patents have been filed and the hydrogel is already available in the rad-nuc market, where the market potential is about $5 billion a year just for the Department of energy's decontamination and decommissioning projects. CBI is also talking with distributors and nearing commercialization for other markets.

It's probably not surprising that the team is spinning again, this time with a spray that creates a barrier against would-be permanent stains. Taggers, be warned.

Biotech Firm Sees Cornea Surgery Success

As published in 2008 August, Pacific Business News by Nanea Kalani:

Five years after setting out to manufacture the delicate tissue that enables the human eye to see clearly, Cellular Bioengineering Inc. has completed 10 successful cornea implants abroad.

The Honolulu biotechnology firm’s patented material for artificial corneas is being manufactured locally and last December was used for eye surgeries in Europe.

Cellular Bioengineering founder and CEO Hank Wuh said the pilot tests help validate the material’s effectiveness, with all patients — who ranged in age from 16 to 75 — regaining sight....read more.

Cellular Bioengineering Snags the Nation's Top R&D Honors

As published in 2005 October, Hawaii Business Magazine by Jacy L. Youn:

And the winner is ... : The R&D 100 award proves CBI's staff is at the top of its game. From left to right: Shaosheng Dong, Michael Coy, Amy Weintraub, Leslie Isaki, Romie Lattrell, Tony Lee, Hank Wuh, Ge Ming Lui, Rosalynn Chan, Kevin Chinn.

The R&D 100 awards. Dubbed "The Oscars of Invention," they are the nation's top honors in research and development, presented annually by R&D Magazine to the companies and organizations behind the best, brightest innovations in America. With former award-winning inventions ranging from the fax machine to the artificial kidney, making the list is no small feat. A fact that isn't lost for a second on Hank Wuh, founder and chief executive officer of Honolulu-based Cellular Bioengineering Inc. (CBI), which this year has been selected an R&D 100 Award recipient, for its development of the Neural Matrix Chip. "It's an honor. It truly is an honor," says Wuh. "They only pick 100 companies each year, and we're very proud to be one of them." ...read more.

Cellular Bioengineering Wins Major R&D Award

As published in 2005 September Pacific Business News by Clynton Namuo:

Cellular Bioengineering Inc. has received one of R&D magazine's R&D 100 Awards, recognizing the world's best innovations in technology in the past year.

The company won the award for its neural matrix chip that allows for the growth of nerve cells in specific patterns on a microchip.

Founder and CEO Hank Wuh is hoping the R&D award will propel his Honolulu-based company into the big leagues of technology companies and generate worldwide attention from corporate and institutional clients....read more.

A Biotech Firm with its Eyes on the Prize

As published in 2005 February, Hawaii Business Magazine by Jacy L. Youn:

Hank Wuh may have successfully avoided the limelight for the past year and a half, ever since he formed the Moiliili-based biotech firm, Cellular Bioengineering Inc. (CBI) in mid-2003. But if things continue to progress as nicely as they have for Wuh and CBI, they may soon be as ubiquitous as David Watumull and Hawaii Biotech are in the world of, well, Hawaii biotech.

Despite CBI's decidedly low-tech location (its lab facilities are located off of Young Street near McCully), the company's 12 employees are working on some very high-tech life science products. Its primary focus is regenerative medicine, or the bioengineering of replacement parts for aging and diseased tissues and organs. CBI's most advanced technology, which involves the growth of cornea (the outermost layer of an eyeball) cells, has potentially a multi-billion dollar market. "Corneal transplants are the most frequently performed human transplant procedure," says Wuh. "But there are still about 10 million people worldwide who are blind from corneal-associated diseases because there aren't enough donors. Our ultimate goal is to eliminate the need for donors entirely." ...read more

A Potential Billion Dollar Company

As published in 2005 February, Pacific Business News, by Terrence Sing:

A new Hawaii company hopes to make the blind see.

Cellular Bioengineering Inc., a biotech startup focused on regenerative medicine, has applied for patents on its proprietary bioengineering of replacement parts for aging, diseased or damaged tissues and organs.

The work the company is doing at its nondescript laboratory in Moiliili has the potential to revolutionize the way organs are replaced and create a life-sciences powerhouse in Honolulu.

In many ways, Cellular Bioengineer-ing is a nearly perfect model for those promoting Hawaii's economic diversification. The company could develop its technology anywhere, but chose Hawaii not only because of its proximity to Asian markets but also because half of its employees are kamaaina who received advanced degrees and came home from the Mainland.

"This is a potential billion-dollar annual revenue company," ....read more.

Greater Good Radio Interview

Radio Interview in 2005 December on Greater Good Radio:

Dr. Hank Wuh has a plan to help millions of blind people to see. Cellular Bioengineering, Inc (CBI) has developed technology to produce corneas to be used in eye transplants. This has been talked about as a multi billion dollar venture with serious social benefit. Dr. Wuh left a promising surgery practice to become a full time inventor and entrepreneur.

Dr. Wuh invented medical devices as a resident at the Stanford University Hospital. He now is an inventor, CEO and investor in the life science field. Hear Dr. Wuh’s unique view of business and how a global mission is the new paradigm.

Some questions asked:
Welcome Hank, can you tell us about the Cellular Bioengineering Inc and what they do?

Does Cellular Bioengineering Inc have a stated business strategy or a “mission statement”?

What’s the story behind Cellular Bioengineering?

What is your role in the company?

Where do you do your science?

Did you ever practice medicine?

How did you become interested in this kind of study?

Congratulations on the award from R&D magazine. The R&D 100 Awards, recognizes the world’s best innovations in technology in the past year. How has the award helped you and your company to further your studies?

How are you able to fund your studies?

What are some of the interesting projects you are working on now?

How do you manage your time?

What do you do to support the community?

What was your experience with venture capitalists?

What do entrepreneurs need to do to raise venture capital?